Just as a primer to those messing with jetting, here are the results of my learnin' based on spending a lot of time tuning my old Seca II. I learned this the hard way, and it's even harder because you have to do everything x4. These are some general tuning tips I've learned by trial-and-error.
* Any time you do anything to increase flow of air or exhaust, you need to richen everything. The opposite is true of restriction.
-From idle to 1/8 throttle or so: Pilot (Idle mixture) screw
-from 1/8 to about 2/3 throttle: needle
-2/3 and up: mains
These areas overlap, but this is a good rule-of-thumb
*watch out for altitude. If you tune at sea level, then go up a few thousand feet, behaviour could be different.
*If you get popping on deceleration (with throttle closed) most likely you are too lean, but you could also have an exhaust leak or air injection problem if your bike is so equipped. This could also be an indication that your pilot jets are becoming clogged if you have made no adjustments, especially if the bike has sat for a while.
*If the bike runs well cold, then develops a hesitation when it warms up, you're too rich.
*If it runs well warm, but is cold-blooded and you have to choke the crap out of it, you're too lean.
*If you install a needle with an aggressive taper, like the KLX needle, and you have stock exhaust, you may have to go DOWN a jet size or two.
*if it hesitates coming off idle when warm, lean up the pilot circuit a hair.
*If it does the same at 1/4 throttle or so, lower the needle a notch.
*If you rejet and actually lose top end, but gain accelleration, the main is probably too rich. (you'll hear a distinct change in tone if you're too rich. )
All of these changes affect the others, so unless you're an expert, you'll have to keep tweaking until you hit that magical driveability balance... where it's smooth throughout the whole range.
Remember. In carburetors, RPM is not important... it is about throttle position.